Molecular Formula | C32H52O2 |
Molar Mass | 468.77 |
Density | 1.02 |
Melting Point | 303-305℃ |
Boling Point | 505.1±49.0 °C(Predicted) |
Specific Rotation(α) | +9 (CHCl3) |
Solubility | Soluble in chloroform, hardly soluble in water |
Appearance | White crystal |
Storage Condition | 2-8℃ |
MDL | MFCD09953818 |
Physical and Chemical Properties | White powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from dandelion. |
In vitro study | Taraxerol acetate(10-150µM; 24 or 48 hours) induces a dose- and time-dependent cytotoxic effects in the U87 cells, exhibits IC 50 values of 34.2 and 28.4µM, at 24 and 48 h, respectively. Taraxerol acetate(10, 50 and 150µM; 24 hours) induces cell apoptosis, the percentage of apoptotic cells increased from 7.3% in the control cells, to 16.1, 44.1 and in the 10, 50 and 150µM taraxerol acetate-treated cells, respectively. Furthermore, taraxerol acetate treatment led to sub-G1cell cycle arrest with a corresponding decrease in the number of S-phase cells. |
biological activity | Taraxerol acetate is a COX-1 and COX-2 inhibitor, the IC50 values were 116.3 μm and 94.7 μm, respectively. Taraxerol acetate has anti-cancer effects and induces apoptosis. |
Use | acetyltaraxacone can inhibit the proliferation of gastric cancer cells. |